|
KMID : 0381120180400030295
|
|
Genes and Genomics
2018 Volume.40 No. 3 p.295 ~ p.304
|
|
|
Characterization of the dynamic change of microRNA expression in mice hypothalamus during the time of female puberty
|
|
Omariba Gideon
Tong Li
Wang Maochun
Li Kai
Zhou Yuxun
Xiao Junhua
|
|
|
Abstract
|
|
|
|
Puberty onset is a milestone in sexual development. A tumor suppress gene (TSG) network had been reported to be involved in the regulation of female puberty onset. The observations in rodents and primates showed a potential link between microRNAs and puberty onset. To figure out what miRNAs play roles in this important biological process, profilings of microRNAs in the hypothalamus of female mice from three different pubertal stages, juvenile [postnatal day (P10)], early pubertal (P25) and pubertal (P30) were performed on the Affymetrix GeneChip miRNA 3.0 Arrays, the cerebral cortex (CTX) was used as a control tissue. 20 miRNAs were shown to be differentially expressed in hypothalamus (fold change?>?1.5, P?
|
|
|
KEYWORD
|
|
|
Mouse hypothalamus, MiRNA array, Puberty onset, Tumor related genes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|